Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenobarbital
Drug ID BADD_D01752
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Indications and Usage For the treatment of all types of seizures except absence seizures.
Marketing Status Not Available
ATC Code N03AA02
DrugBank ID DB01174
KEGG ID D00506
MeSH ID D010634
PubChem ID 4763
TTD Drug ID D0Y7RW
NDC Product Code 58118-0626; 16571-673; 69336-115; 75826-136; 71205-889; 0143-1495; 17856-0502; 66064-2001; 63629-2404; 16571-668; 63629-2289; 70752-167; 0603-5166; 70518-0822; 69367-212; 76003-0894; 16571-669; 51927-1015; 67296-1427; 0603-5165; 70518-2612; 51293-626; 16571-674; 69367-214; 63629-2043; 70752-162; 63629-2049; 63739-294; 58118-1110; 16571-675; 69367-213; 64380-166; 71205-892; 70752-168; 63739-192; 13517-111; 63629-2045; 70752-161; 65319-1450; 0143-1458; 0603-5167; 63629-2044; 13517-110; 51293-627; 63629-2402; 51293-693; 75826-143; 38779-0852; 51293-694; 63187-895; 63629-2047; 51293-692; 43063-953; 70752-165; 70518-0722; 70752-164; 70752-166; 17856-0174; 63629-2046; 51293-625; 69367-211; 70518-2418; 63629-2401; 71205-891; 59348-0011; 63629-2041; 13517-758; 70166-536; 71205-890; 13517-756; 69336-116; 60687-448; 69336-117; 13517-113; 13517-112; 0121-0531; 63629-2400; 0143-1455; 63629-2403; 70518-2407; 58624-0520; 70166-537; 16571-667; 0603-5168; 75826-142; 0904-6575; 63629-2291; 61919-109; 75826-141; 70752-163; 63629-2399; 63629-2042; 70518-2405; 13517-755; 16571-671; 63629-2290; 0143-1500; 75826-139; 75826-138; 69367-172; 51552-0745; 16571-672; 13517-757; 51293-691; 16571-670; 63629-2048; 63629-1033; 13517-107; 69336-118; 51293-628; 49452-5190; 0395-8090; 71205-893; 54932-207; 75826-137; 0603-1508; 54932-501; 63629-1032; 75826-140; 70752-157
Synonyms Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal
Chemical Information
Molecular Formula C12H12N2O3
CAS Registry Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Toxicity to various agentsCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nystagmus17.02.02.006; 06.05.02.0060.001490%
Osteomalacia15.02.03.001; 14.04.04.001; 20.01.01.002--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis acute07.18.01.0020.002235%Not Available
Petit mal epilepsy17.12.04.0010.001490%Not Available
Phobia19.06.03.002--Not Available
Pneumonia aspiration22.01.01.0050.000777%Not Available
Psychomotor retardation19.15.02.0020.001490%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.001490%
Pyrexia08.05.02.0030.003725%
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.0090.000389%Not Available
Respiratory depression17.02.05.047; 22.02.01.0100.001490%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Seizure17.12.03.0010.011175%
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.0060.002235%
Status epilepticus17.12.03.0050.002235%Not Available
Stevens-Johnson syndrome11.07.01.005; 10.01.03.020; 23.03.01.007; 12.03.01.0140.002235%
Suicidal ideation19.12.01.003--
Suppressed lactation21.05.02.003; 18.06.02.001--Not Available
Swelling face10.01.05.018; 23.04.01.018--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.0060.000389%
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