| Drug Name |
Pertuzumab |
| Drug ID |
BADD_D01744 |
| Description |
Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal antibody, [trastuzumab], in the treatment of metastatic HER2-positive breast cancer. Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.[L14642,L14772] |
| Indications and Usage |
Pertuzumab is indicated for use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. |
| Marketing Status |
Prescription |
| ATC Code |
L01FD02 |
| DrugBank ID |
DB06366
|
| KEGG ID |
D05446
|
| MeSH ID |
C485206
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D0CI4E
|
| NDC Product Code |
50242-145; 50242-144 |
| Synonyms |
pertuzumab | Perjeta | RG-1273 | rhumab 2C4 | rhumab-2C4 | Omnitarg | Omnitarg, 2C4 |
