Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Periciazine
Drug ID BADD_D01738
Description Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Indications and Usage For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.
Marketing Status Not Available
ATC Code N05AC01
DrugBank ID DB01608
KEGG ID D01485
MeSH ID C084584
PubChem ID 4747
TTD Drug ID D00AWT
NDC Product Code Not Available
Synonyms periciazine | propericiazine | pericyazine | Neuleptil | Neuleptyl | Aolept
Chemical Information
Molecular Formula C21H23N3OS
CAS Registry Number 2622-26-6
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Akinesia17.01.02.003--Not Available
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrioventricular block02.03.01.002--Not Available
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dental caries07.09.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dyspnoea22.02.01.004; 02.01.03.002--
Electrocardiogram ST segment depression13.14.05.005--Not Available
Embolism venous24.01.01.003--Not Available
Eosinophilia01.02.04.001--
Galactorrhoea05.03.04.002; 21.05.02.002--Not Available
Glaucoma06.03.01.002--
Gynaecomastia21.05.04.003; 05.05.02.003--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
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