Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pentazocine hydrochloride
Drug ID BADD_D01719
Description The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Indications and Usage For the relief of moderate to severe pain.
Marketing Status approved; vet_approved
ATC Code N02AD01
DrugBank ID DB00652
KEGG ID D02227
MeSH ID D010423
PubChem ID 441277
TTD Drug ID D0W6DG
NDC Product Code 17337-0028; 48087-0077
UNII A36BXO4PPX
Synonyms Pentazocine | Lexir | Pentazocine Lactate | Lactate, Pentazocine | Talwin | Fortral | Pentazocine Hydrochloride | Hydrochloride, Pentazocine
Chemical Information
Molecular Formula C19H28ClNO
CAS Registry Number 64024-15-3
SMILES CC1C2CC3=C(C1(CCN2CC=C(C)C)C)C=C(C=C3)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Loss of consciousness17.02.04.004--Not Available
Miosis17.02.11.002; 06.05.03.003--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nystagmus17.02.02.006; 06.05.02.006--
Paraesthesia23.03.03.094; 17.02.06.005--
Pruritus23.03.12.001--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.11.04.015--
Tachycardia02.03.02.007--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.002--
Ulcer08.03.06.001--Not Available
Urinary retention20.02.02.011--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.003--
Uterine contractions during pregnancy18.08.02.005--Not Available
Nodule08.03.05.002--Not Available
Induration08.01.03.020--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Pulmonary function test decreased13.19.01.001--Not Available
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