Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penicillin v potassium
Drug ID BADD_D01716
Description Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK.[A178609] It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, skin, and soft tissues caused by penicillin G­-sensitive microorganisms. Phenoxymethylpenicillin has also be used in some cases as prophylaxis against susceptible organisms. While there have been no controlled clinical efficacy studies that were conducted, phenoxymethylpenicillin has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract, except for those who are at an elevated risk for endocarditis.[label]
Indications and Usage For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms.
Marketing Status Discontinued; Prescription
ATC Code J01CE02
DrugBank ID DB00417
KEGG ID D00497
MeSH ID D010404
PubChem ID 23676814
TTD Drug ID D02IIE
NDC Product Code 68071-4838; 70518-2758; 68071-4697; 53002-2020; 43063-680; 42708-098; 70518-3052; 63187-045; 65862-175; 63187-926; 68071-2244; 63629-7619; 50090-3837; 43063-780; 63629-7617; 63187-756; 68071-4473; 0143-9836; 50090-5543; 63187-533; 0093-1174; 72789-245; 67296-1326; 65862-176; 16714-234; 53002-2010; 68788-7136; 55657-102; 43063-995; 61919-649; 63629-7626; 50090-3210; 68071-4298; 68071-3299; 68788-9853; 50090-3307; 57237-041; 0093-4127; 43063-704; 57237-040; 68788-9852; 43063-557; 53002-2130; 67296-1289; 68071-4753; 50090-0408; 68071-1820; 67296-1135; 67296-0988; 50090-2287; 70518-2877; 72789-223; 72789-146; 68071-2457; 50090-3506; 50090-2286; 50090-3374; 68071-4160; 16714-235; 43063-614; 72789-222; 63629-7623; 63629-7616; 63629-7624; 50090-4651; 54563-002; 50090-0409; 50090-4652; 0143-9837; 70934-076; 0093-4125; 50090-3425; 63187-676; 43063-622; 66267-160; 68071-2515; 43063-576; 68071-5081; 68071-4645; 63629-7627; 0093-1172
Synonyms Penicillin V | Fenoxymethylpenicillin | Phenoxymethylpenicillin | Penicillin, Phenoxymethyl | Phenoxymethyl Penicillin | Beromycin | Beromycin, Penicillin | Penicillin Beromycin | Berromycin, Penicillin | Penicillin Berromycin | Betapen | Pen VK | Penicillin VK | Penicillin V Sodium | Sodium, Penicillin V | V Sodium, Penicillin | V-Cillin K | V Cillin K | VCillin K | Vegacillin | Apocillin | Penicillin V Potassium | Potassium, Penicillin V
Chemical Information
Molecular Formula C16H17KN2O5S
CAS Registry Number 132-98-9
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)COC3=CC=CC=C3)C(=O)[O-])C.[K+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionGlial fibrillary acidic proteinP14136Not AvailableNot Available
DepressionGlial fibrillary acidic proteinP14136Not AvailableNot Available
DepressionProtein c-FosP01100T28025Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Death08.04.01.001--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Haemolytic anaemia01.06.03.002--Not Available
Hypersensitivity10.01.03.003--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Nephropathy20.05.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tongue discolouration07.14.02.006--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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