Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penbutolol sulfate
Drug ID BADD_D01707
Description Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects. This binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity.
Indications and Usage Penbutolol is indicated in the treatment of mild to moderate arterial hypertension. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity.
Marketing Status approved; investigational
ATC Code C07AA23
DrugBank ID DB01359
KEGG ID D00602
MeSH ID D010394
PubChem ID 38010
TTD Drug ID D0W8SB
NDC Product Code 48954-699
UNII US71433228
Synonyms Penbutolol | Penbutolol Sulfate | Sulfate, Penbutolol | Penbutolol Sulfate (2:1) | Betapressin | Hoe-893d | Hoe 893d | Hoe893d
Chemical Information
Molecular Formula C36H60N2O8S
CAS Registry Number 38363-32-5
SMILES CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O) O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Catatonia19.11.01.001--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Insomnia19.02.01.002; 17.15.03.002--
Laryngospasm22.04.02.002--
Mesenteric artery thrombosis07.15.02.008; 24.01.08.003--Not Available
Nausea07.01.07.001--
Pain in extremity15.03.04.010--
Peyronie's disease21.12.01.002--Not Available
Purpura01.01.04.003; 24.07.06.005; 23.06.01.004--
Pyrexia08.05.02.003--
Rash erythematous23.03.13.029--Not Available
Respiratory distress22.02.01.012--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
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