Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status Prescription
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 65129-1366; 42367-531; 47848-026
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus generalised23.03.12.0030.000533%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Febrile bone marrow aplasia08.05.02.005; 01.03.03.0070.000278%Not Available
Hepatic cancer metastatic16.07.02.002; 09.04.02.006--Not Available
Pulmonary mass22.02.07.0040.000533%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000139%Not Available
Bicytopenia01.03.03.0100.000799%Not Available
Extremity necrosis24.04.03.012--Not Available
Embolism24.01.01.009--
Haematotoxicity12.03.01.025; 01.05.01.0070.001066%Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Neoplasm progression16.16.02.0050.000625%Not Available
Oral fungal infection11.03.05.010; 07.05.07.0090.000139%Not Available
Decreased appetite08.01.09.028; 14.03.01.0050.002398%
Blood disorder01.05.01.004--Not Available
Disease progression08.01.03.0380.000486%
Drug intolerance08.06.01.013--Not Available
Gastrointestinal obstruction07.13.01.005--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.0100.000533%Not Available
Neutropenic colitis07.08.01.014; 01.02.03.0100.000139%Not Available
Bone marrow failure01.03.03.0050.000486%
Ocular surface disease06.08.03.016--Not Available
Acute kidney injury20.01.03.0160.001529%
Candida infection11.03.03.0210.000799%
Sopor19.02.04.002; 17.02.04.0210.000533%Not Available
Clostridium test positive13.08.01.0070.000533%Not Available
The 7th Page    First    Pre   7    Total 7 Pages