Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status approved; investigational
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 16729-244; 0338-0722; 0409-0021; 70121-1233; 47848-026; 65129-1366; 55150-383; 0409-3532; 55150-381; 0409-1045; 68001-537; 0409-0020; 0409-1061; 0480-4514; 16729-230; 55150-382; 68001-547; 0480-4515; 0480-4516; 0338-0720; 16729-229; 68001-535; 68001-549; 0409-0004; 0409-2188; 68001-536; 42367-531; 68001-548; 0409-1060; 70121-1232
UNII 04Q9AIZ7NO
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary mass22.02.07.0040.000112%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000168%Not Available
Bicytopenia01.03.03.0100.000224%Not Available
Metastases to central nervous system17.02.10.013; 16.22.02.0040.000112%Not Available
Extremity necrosis24.04.03.012--Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.0010.000112%
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Embolism24.01.01.009--
Haematotoxicity12.03.01.025; 01.05.01.0070.000280%Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Malnutrition14.03.02.0040.000168%Not Available
Neoplasm progression16.16.02.0050.000672%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000862%
Blood disorder01.05.01.004--Not Available
Disease progression08.01.03.0380.000336%
Gastrointestinal obstruction07.13.01.005--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.0100.000336%Not Available
Neutropenic colitis07.08.01.014; 01.02.03.0100.000112%Not Available
Osteonecrosis of jaw24.04.05.005; 15.02.04.0100.000112%
Chronic kidney disease20.01.03.0170.000112%
Bone marrow failure01.03.03.0050.000392%
Ocular surface disease06.08.03.016--Not Available
Type 1 diabetes mellitus14.06.01.010; 10.04.08.007; 05.06.01.010--Not Available
Hypertransaminasaemia09.01.02.0050.000280%Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.000112%
Acute kidney injury20.01.03.0160.001567%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000112%Not Available
Sopor19.02.04.002; 17.02.04.0210.000112%Not Available
Hypercreatininaemia20.01.02.016; 14.11.01.0390.000112%Not Available
The 7th Page    First    Pre   7 8    Next   Last    Total 8 Pages