Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status Prescription
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 65129-1366; 42367-531; 47848-026
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Feeling hot08.01.09.0090.000799%Not Available
Flushing23.06.05.003; 24.03.01.002; 08.01.03.0250.000799%
Gamma-glutamyltransferase increased13.03.01.011--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.003--
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.0040.000799%
Glomerular filtration rate decreased13.13.01.009--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Heart rate increased13.14.04.0020.000533%Not Available
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.0080.001865%Not Available
Herpes virus infection11.05.02.0080.000533%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000799%
Hyperhidrosis23.02.03.004; 08.01.03.0280.000533%
Hyperkalaemia14.05.03.0010.000799%
Hyperpyrexia08.05.02.0020.000799%Not Available
Hypersensitivity10.01.03.0030.000799%
Hypertension24.08.02.001--
Hypokalaemia14.05.03.0020.000799%
Hyponatraemia14.05.04.0020.001066%
Hypotension24.06.03.0020.001332%
Hypoxia22.02.02.0030.000799%
Infection11.01.08.0020.000139%Not Available
Interstitial lung disease10.02.01.033; 22.01.02.0030.005328%Not Available
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000208%Not Available
Intestinal obstruction07.13.01.0020.000533%Not Available
Intestinal perforation07.04.06.002--Not Available
Lacrimation increased06.08.02.004--
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