Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastric ulcer haemorrhage24.07.02.003; 07.04.03.0050.000112%Not Available
Gastritis07.08.02.0010.000604%
Gastritis erosive07.04.03.0030.000112%Not Available
Gastrointestinal fistula07.11.05.001--
Gastrooesophageal reflux disease07.02.02.0030.002899%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.0010.000560%Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.000280%
Genital ulceration23.07.03.004; 21.10.05.0010.000302%Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.000951%Not Available
Gingival pain07.09.13.0100.000112%
Gingival swelling07.09.13.0130.000112%Not Available
Gingivitis07.09.10.002; 11.01.04.013--
Glossitis07.14.01.0010.000548%Not Available
Glossodynia07.14.02.0010.001421%Not Available
Goitre14.11.01.008; 05.02.01.0010.000112%Not Available
Groin pain15.03.02.0040.000302%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.001254%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.001198%Not Available
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.0060.001713%
Haemoglobin13.01.05.018--Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.000168%
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.0040.002563%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.000694%
Haemothorax12.01.18.005; 24.07.01.008; 22.05.02.0010.000112%
Hair colour changes23.02.06.0010.033366%
Hair texture abnormal23.02.06.0040.000381%
Headache17.14.01.0010.020774%
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