Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status Prescription; Discontinued
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Colitis ulcerative10.02.01.004; 07.08.01.0050.001332%Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.0010.014919%
Cyst16.02.02.002; 08.03.05.001--Not Available
Cystitis20.03.02.002; 11.01.14.0010.001332%
Deafness04.02.01.0010.001598%Not Available
Death08.04.01.0010.052819%
Decreased activity19.11.01.002; 08.01.01.0060.000533%Not Available
Decreased immune responsiveness10.02.01.0410.000799%Not Available
Decubitus ulcer23.03.11.0060.000533%Not Available
Defaecation urgency07.02.04.0010.000533%Not Available
Dehydration14.05.05.0010.013853%
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.0020.001332%Not Available
Dermatitis allergic10.01.03.014; 23.03.04.003--Not Available
Dermatitis bullous23.03.01.002--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.183291%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.000799%Not Available
Diffuse large B-cell lymphoma16.28.02.001; 01.15.02.0010.000139%Not Available
Dilatation ventricular02.04.02.0260.000799%Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
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