Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status approved; vet_approved
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 0703-3213; 52222-0001; 65129-1308; 68083-179; 69539-159; 62422-0004; 68001-516; 68083-178; 0703-4768; 68554-0061; 46708-622; 47781-595; 62332-621; 62332-622; 63323-763; 72205-063; 60505-6230; 62332-620; 72205-062; 0517-4300; 0703-3216; 0703-3218; 17359-3055; 63126-902; 69539-158; 72205-061; 17359-4056; 49452-4961; 51446-0110; 59651-605; 0703-4764; 51446-0120; 46708-620; 61703-342; 68083-180; 0703-3217; 17359-4040; 62422-0002; 69539-157; 70860-215; 42533-111; 54893-0007; 65129-2039; 69443-022; 16714-137; 68817-134; 70860-200; 17359-4055; 65892-002; 24979-710; 46708-621
UNII P88XT4IS4D
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Optic neuropathy06.02.08.002; 17.04.05.0050.000168%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Corneal disorder06.08.01.0040.000224%Not Available
Respiratory fume inhalation disorder22.02.07.009; 12.03.02.003--Not Available
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Blood disorder01.05.01.0040.000168%Not Available
Immunodeficiency10.03.02.002--Not Available
Adverse drug reaction08.06.01.009--Not Available
Autonomic neuropathy17.05.01.009--Not Available
Demyelinating polyneuropathy17.09.04.003; 10.04.10.0070.000168%Not Available
Disease progression08.01.03.0380.008596%
Disease recurrence08.01.03.050--Not Available
Drug intolerance08.06.01.013--Not Available
Neoplasm recurrence16.16.02.0040.000112%Not Available
Non-small cell lung cancer22.08.01.002; 16.19.01.0010.001119%Not Available
Obstructive airways disorder22.03.01.0110.000694%Not Available
Cranial nerve paralysis17.04.01.0020.000112%Not Available
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000895%Not Available
Hepatic lesion09.01.08.0050.000112%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Large intestinal obstruction07.13.03.0030.000112%
Pigmentation disorder23.05.03.0010.000112%Not Available
Metabolic encephalopathy17.13.01.001; 14.11.01.013--Not Available
Renal impairment20.01.03.010--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Neutropenic colitis07.08.01.014; 01.02.03.0100.000224%Not Available
Facial spasm17.04.03.0100.000224%Not Available
Chronic allograft nephropathy20.01.02.010; 12.02.10.005; 10.02.03.0040.000112%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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