ADReCS

Pharmaceutical Information

Drug Name	Paclitaxel
Drug ID	BADD_D01653
Description	Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage	Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status	approved; vet_approved
ATC Code	L01CD01
DrugBank ID	DB01229
KEGG ID	D00491
MeSH ID	D017239
PubChem ID	36314
TTD Drug ID	D0C4RB
NDC Product Code	0703-3213; 52222-0001; 65129-1308; 68083-179; 69539-159; 62422-0004; 68001-516; 68083-178; 0703-4768; 68554-0061; 46708-622; 47781-595; 62332-621; 62332-622; 63323-763; 72205-063; 60505-6230; 62332-620; 72205-062; 0517-4300; 0703-3216; 0703-3218; 17359-3055; 63126-902; 69539-158; 72205-061; 17359-4056; 49452-4961; 51446-0110; 59651-605; 0703-4764; 51446-0120; 46708-620; 61703-342; 68083-180; 0703-3217; 17359-4040; 62422-0002; 69539-157; 70860-215; 42533-111; 54893-0007; 65129-2039; 69443-022; 16714-137; 68817-134; 70860-200; 17359-4055; 65892-002; 24979-710; 46708-621
UNII	P88XT4IS4D
Synonyms	Paclitaxel \| Anzatax \| NSC-125973 \| NSC 125973 \| NSC125973 \| Taxol \| Taxol A \| Bris Taxol \| Taxol, Bris \| Paclitaxel, (4 alpha)-Isomer \| Paxene \| Praxel \| 7-epi-Taxol \| 7 epi Taxol \| Onxol

Chemical Information

Molecular Formula	C47H51NO14
CAS Registry Number	33069-62-4
SMILES	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Somnolence	19.02.05.003; 17.02.04.006	-	-
Splenomegaly	01.09.02.001	-	-	Not Available
Squamous cell carcinoma of lung	16.19.01.006; 22.08.01.014	-	-	Not Available
Stevens-Johnson syndrome	10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005	-	-
Stomatitis	07.05.06.005	0.002563%
Stridor	22.04.02.003	0.000302%
Stupor	19.02.05.004; 17.02.04.007	0.000112%		Not Available
Sudden death	02.03.04.013; 08.04.01.003	0.000392%
Suffocation feeling	22.12.02.014	0.000280%		Not Available
Supraventricular tachycardia	02.03.03.012	-	-
Swelling	08.01.03.015	-	-	Not Available
Swelling face	08.01.03.100; 23.04.01.018; 10.01.05.018	0.001354%		Not Available
Syncope	17.02.04.008; 02.11.04.015; 24.06.02.012	0.002843%
Systemic lupus erythematosus	23.03.02.006; 15.06.02.003; 10.04.03.004	0.000280%		Not Available
Tachycardia	02.03.02.007	0.007007%		Not Available
Tachypnoea	22.02.01.014	0.000448%		Not Available
Tenderness	08.01.08.005	0.000168%		Not Available
Tension	19.06.02.005	-	-	Not Available
Thinking abnormal	19.10.03.001; 17.02.05.023	-	-	Not Available
Throat irritation	22.12.03.029; 07.05.05.037	0.002183%		Not Available
Throat tightness	22.12.03.031; 19.01.02.005	0.004533%		Not Available
Thrombocytopenia	01.08.01.002	0.008048%		Not Available
Thrombocytopenic purpura	23.06.01.007; 01.08.01.003	0.000168%		Not Available
Thrombocytosis	01.08.02.001	0.000224%		Not Available
Thrombophlebitis	24.01.02.001	0.000280%		Not Available
Thrombosis	24.01.01.006	-	-	Not Available
Thrombosis mesenteric vessel	24.01.08.001; 07.15.02.004	-	-	Not Available
Thrombotic microangiopathy	01.01.02.006; 24.01.01.013; 20.01.07.004	0.000392%		Not Available
Thrombotic thrombocytopenic purpura	24.07.06.014; 23.06.01.011; 01.08.01.005	0.000168%
Tinnitus	17.04.07.004; 04.04.01.002	-	-

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