Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status Prescription; Discontinued
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 59390-140; 68047-713; 68071-2544; 71205-420; 63187-472; 55111-161; 71209-097; 75834-119; 68071-1588; 68788-7693; 24208-434; 63187-268; 71209-098; 11980-779; 70518-1892; 68071-2254; 68071-1607; 50383-024; 64980-515; 71209-099; 50090-5425; 50090-1090; 58032-0090; 63187-184; 63187-734; 13985-602; 55111-160; 68071-1630; 68071-5150; 63187-662; 68071-2265; 68071-4832; 50090-5186; 53002-1324; 75834-120; 55111-162; 53002-1604; 59116-1820; 50090-5209; 50090-0891; 60505-0363; 53002-2604; 60505-0560; 50090-1346; 50090-5210; 72969-108; 24208-410; 63629-8716; 0404-7189; 61919-931; 75834-112; 17478-713; 72189-108; 53069-0440
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vision blurred17.17.01.010; 06.02.06.0070.000398%
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Vulvovaginal candidiasis21.14.02.003; 11.03.03.005--Not Available
Weight decreased13.15.01.005--
Tubulointerstitial nephritis20.05.02.0020.000398%Not Available
Hypoacusis04.02.01.006--
Balance disorder17.02.02.0070.000398%Not Available
Contusion12.01.06.001; 24.07.06.001; 23.03.11.002; 15.03.01.008--
Candiduria20.02.01.016; 11.03.03.009--Not Available
Eyelids pruritus23.03.12.005; 06.08.03.007--Not Available
Eye oedema06.08.03.013--Not Available
Eye pruritus06.04.05.006--Not Available
Ocular discomfort06.08.03.008--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Chemical eye injury12.03.02.005; 06.11.01.007--Not Available
Haemorrhage24.07.01.002--Not Available
Vasodilation procedure25.03.01.001--Not Available
Drug resistance08.06.01.0050.000104%Not Available
Urine output increased13.13.03.002--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Inflammation08.01.05.007--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
Sensation of foreign body08.01.09.002--Not Available
Chondropathy15.07.03.0030.000398%Not Available
Psychotic disorder19.03.01.002--
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