Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status Prescription; Discontinued
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 59390-140; 68047-713; 68071-2544; 71205-420; 63187-472; 55111-161; 71209-097; 75834-119; 68071-1588; 68788-7693; 24208-434; 63187-268; 71209-098; 11980-779; 70518-1892; 68071-2254; 68071-1607; 50383-024; 64980-515; 71209-099; 50090-5425; 50090-1090; 58032-0090; 63187-184; 63187-734; 13985-602; 55111-160; 68071-1630; 68071-5150; 63187-662; 68071-2265; 68071-4832; 50090-5186; 53002-1324; 75834-120; 55111-162; 53002-1604; 59116-1820; 50090-5209; 50090-0891; 60505-0363; 53002-2604; 60505-0560; 50090-1346; 50090-5210; 72969-108; 24208-410; 63629-8716; 0404-7189; 61919-931; 75834-112; 17478-713; 72189-108; 53069-0440
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus genital21.10.01.002; 23.03.12.008--Not Available
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyelonephritis11.01.14.002; 20.01.09.0010.000398%Not Available
Pyrexia08.05.02.0030.000398%
Pyuria20.02.01.012; 11.01.08.043--Not Available
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Rash follicular23.03.10.001--Not Available
Rash maculo-papular23.03.13.0040.000995%
Rash papular23.03.13.0170.000398%Not Available
Rash pustular23.03.10.003; 11.01.12.002--
Renal failure20.01.03.0050.000104%Not Available
Respiratory arrest22.02.01.009--Not Available
Rhabdomyolysis15.05.05.0020.000156%
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.02.05.010--
Seborrhoea23.02.07.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Sensory loss17.02.07.007--Not Available
Serum sickness12.02.08.004; 10.01.03.004--
Sexually transmitted disease11.01.08.034--Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin hyperpigmentation23.05.01.003--
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.0050.000156%
Stomatitis07.05.06.0050.000398%
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