Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status Prescription; Discontinued
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 59390-140; 68047-713; 68071-2544; 71205-420; 63187-472; 55111-161; 71209-097; 75834-119; 68071-1588; 68788-7693; 24208-434; 63187-268; 71209-098; 11980-779; 70518-1892; 68071-2254; 68071-1607; 50383-024; 64980-515; 71209-099; 50090-5425; 50090-1090; 58032-0090; 63187-184; 63187-734; 13985-602; 55111-160; 68071-1630; 68071-5150; 63187-662; 68071-2265; 68071-4832; 50090-5186; 53002-1324; 75834-120; 55111-162; 53002-1604; 59116-1820; 50090-5209; 50090-0891; 60505-0363; 53002-2604; 60505-0560; 50090-1346; 50090-5210; 72969-108; 24208-410; 63629-8716; 0404-7189; 61919-931; 75834-112; 17478-713; 72189-108; 53069-0440
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal pain07.01.05.005--
Glycosuria20.02.01.005--
Gonorrhoea11.02.14.005--Not Available
Haematoma24.07.01.0010.000398%
Haematuria20.02.01.006; 24.07.01.047--
Haemoglobin13.01.05.018--Not Available
Hallucination19.10.02.0020.000398%
Hallucination, auditory19.10.02.0030.000398%Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.0080.000597%Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hostility19.05.01.003--Not Available
Hyperaemia24.03.02.002--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.0030.000398%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hyposthenuria20.02.01.008--Not Available
Hypotension24.06.03.0020.000104%
Hypovolaemic shock24.06.02.0170.000104%Not Available
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
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