Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norepinephrine bitartrate
Drug ID BADD_D01584
Description Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Indications and Usage Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Marketing Status Prescription; Discontinued
ATC Code C01CA03
DrugBank ID DB00368
KEGG ID D05206
MeSH ID D009638
PubChem ID 3047796
TTD Drug ID D07MOX
NDC Product Code 51662-1528; 51927-4533; 38779-2138; 63275-9861; 36000-162; 67457-852; 51991-983; 25021-316; 63323-940; 12828-0064; 0781-3755; 70121-1576; 0703-1153; 65832-0001; 47335-615; 65392-2301; 72572-481; 68083-437; 0338-0108; 66300-001; 0409-3375; 43066-997; 66064-1025; 0143-9318; 72078-002; 0338-0112
Synonyms Norepinephrine | Levonorepinephrine | Noradrenaline | Levarterenol | Levophed | Levophed Bitartrate | Noradrénaline tartrate renaudin | Norepinephrine Bitartrate | Norepinephrine l-Tartrate (1:1) | Noradrenaline Bitartrate | Norepinephrine d-Tartrate (1:1) | Norepinephrin d-Tartrate (1:1) | Norepinephrine Hydrochloride | Norepinephrine Hydrochloride, (+)-Isomer | Norepinephrine Hydrochloride, (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), Monohydrate | Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer | Norepinephrine l-Tartrate (1:2) | Norepinephrine l-Tartrate, (+)-Isomer | Norepinephrine, (+)-Isomer | Norepinephrine, (+,-)-Isomer | Arterenol | Levonor
Chemical Information
Molecular Formula C12H19NO10
CAS Registry Number 108341-18-0
SMILES C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.003--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Injection site extravasation12.07.03.002; 08.02.03.002--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Photophobia17.17.02.006; 06.01.01.004--
Respiratory disorder22.02.07.002--Not Available
Vomiting07.01.07.003--
Ischaemia24.04.02.004--Not Available
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