| Drug Name |
Nitrofurantoin (monohydrate/macrocrystals) |
| Drug ID |
BADD_D01578 |
| Description |
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830]
Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] |
| Indications and Usage |
May be used as an alternative in the treatment of urinary tract infections. May be used by females pericoitally for prophylaxis against recurrent cystitis related to coitus. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01XE01 |
| DrugBank ID |
DB00698
|
| KEGG ID |
D00439
|
| MeSH ID |
D009582
|
| PubChem ID |
6604200
|
| TTD Drug ID |
D0R0BX
|
| NDC Product Code |
72789-234; 72789-242; 68084-446; 53002-7041; 71205-546; 50090-3856; 0185-0122; 60760-194; 16714-439; 59746-762; 68788-7092; 68071-4428; 63629-1748; 63187-995; 76420-195; 68071-4367; 55700-822; 70518-1087; 50090-3737; 63629-1459; 68071-5076 |
| Synonyms |
Nitrofurantoin | Furadoine | Nitrofurantoin, Monohydrate | Furantoin | Macrodantin | Nitrofurantoin Sodium Salt | Furadantin | Furadantine | Furadonine |
