Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitric oxide
Drug ID BADD_D01574
Description Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Indications and Usage For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Marketing Status Prescription; Discontinued
ATC Code R07AX01
DrugBank ID DB00435
KEGG ID D00074
MeSH ID D009569
PubChem ID 145068
TTD Drug ID D0A5FM
NDC Product Code 72385-001; 80519-301; 64693-002
Synonyms Nitric Oxide | Oxide, Nitric | Nitrogen Monoxide | Monoxide, Nitrogen | Nitric Oxide, Endothelium-Derived | Endothelium-Derived Nitric Oxide | Nitric Oxide, Endothelium Derived | Endogenous Nitrate Vasodilator | Nitrate Vasodilator, Endogenous | Vasodilator, Endogenous Nitrate | Mononitrogen Monoxide | Monoxide, Mononitrogen
Chemical Information
Molecular Formula NO
CAS Registry Number 10102-43-9
SMILES [N]=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisNoc7E5DUJ3Not AvailableNot Available
ApoptosisNADP-dependent oxidoreductase 3W4JPE0Not AvailableNot Available
ApoptosisGolgi SNAP receptor complex member 1O95249Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Methaemoglobinaemia01.05.01.002-
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Oxygen saturation decreased13.02.01.004-Not Available
Persistent foetal circulation24.03.03.004; 18.04.07.001; 03.07.01.002; 02.08.02.001-Not Available
Pneumothorax22.05.02.003-
Premature baby18.04.02.001-Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.003-
Pulmonary hypertension22.06.01.001; 24.08.03.002-
Pulmonary oedema22.01.03.003; 02.05.02.003-
Rebound effect08.06.02.009-Not Available
Respiratory failure22.02.06.002; 14.01.04.003-
Right ventricular failure02.05.03.002-Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003-
Shock24.06.02.002-Not Available
Thrombocytopenia01.08.01.002--Not Available
Ventricular fibrillation02.03.04.008-
Ventricular tachycardia02.03.04.010-
Neonatal hypoxia22.11.02.002; 18.04.15.002-Not Available
Lymphatic disorder01.09.01.003--Not Available
Periventricular leukomalacia17.13.02.005; 18.04.07.003--Not Available
Cerebral haematoma17.08.01.014; 24.07.04.006-Not Available
Haemorrhage24.07.01.002-Not Available
Paraesthesia oral07.05.03.003; 17.02.06.008-Not Available
Cognitive disorder19.21.02.001; 17.03.03.003-
Angiopathy24.03.02.007--Not Available
Cardiac disorder02.01.01.003-Not Available
Mediastinal disorder22.09.03.001--Not Available
Motor dysfunction17.02.10.004-Not Available
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