Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T2265810453373; 9361176; 9753275
Drug tolerance increasedCholine O-acetyltransferaseP28329Not Available3712280; 1528936; 3772799; 1920127
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not Available25954131
Tardive dyskinesiaCytochrome P450 1A2P05177Not Available10889552; 11496364; 15564895
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug dependence19.07.02.0090.178619%Not Available
Drug hypersensitivity10.01.01.0010.026793%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.007655%Not Available
Drug withdrawal syndrome neonatal19.07.02.012; 18.04.13.001; 08.06.02.0080.026793%Not Available
Dry eye06.08.02.0010.002552%
Dry mouth07.06.01.0020.006379%
Dry skin23.03.03.001--
Dry throat22.02.05.004; 07.06.01.0050.003828%Not Available
Dysarthria19.19.03.001; 17.02.08.0010.002552%
Dysgeusia17.02.07.003; 07.14.03.0010.012758%
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.0010.005103%
Dysphagia07.01.06.003--
Dysphonia19.19.03.002; 17.02.08.004; 22.02.05.005--
Dyspnoea22.02.01.004; 02.01.03.0020.033172%
Ear pain04.03.01.003--
Eclampsia24.08.07.001; 18.02.03.001; 17.12.03.012; 20.01.08.0010.003828%Not Available
Electrocardiogram abnormal13.14.05.0010.003828%Not Available
Emotional disorder19.04.02.0050.002552%Not Available
Epilepsy17.12.03.0020.005103%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Erythema23.03.06.001--Not Available
Extrasystoles02.03.02.003--Not Available
Eye irritation06.04.05.0030.002552%Not Available
Eye pain06.08.03.0020.002552%
Fallot's tetralogy02.08.01.002; 03.07.06.0010.002552%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.020414%Not Available
Flat affect19.04.01.004--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 13 Pages