Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T2265810453373; 9361176; 9753275
Drug tolerance increasedCholine O-acetyltransferaseP28329Not Available3712280; 1528936; 3772799; 1920127
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not Available25954131
Tardive dyskinesiaCytochrome P450 1A2P05177Not Available10889552; 11496364; 15564895
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cleft palate07.05.08.001; 03.04.02.0010.002552%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.0100.003661%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Congenital cystic kidney disease20.01.04.006; 16.27.01.002; 03.06.01.0030.002552%Not Available
Constipation07.02.02.0010.010207%
Convulsion neonatal18.04.04.003; 17.12.03.0170.003828%Not Available
Coordination abnormal17.02.02.004--Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.0010.025517%
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.002552%Not Available
Cystitis20.03.02.002; 11.01.14.001--
Death08.04.01.001--
Dehydration14.05.05.001--
Dental caries07.09.01.0010.007655%
Dependence19.07.02.0030.014034%Not Available
Depression19.15.01.0010.015310%
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.008931%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.005103%Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.0020.003828%Not Available
Discomfort08.01.08.003--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000998%
Disturbance in attention19.21.02.002; 17.03.03.0010.010207%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.033172%
Drooling17.02.05.0050.002552%Not Available
Drug abuse19.07.02.0100.005991%Not Available
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