ADReCS

Pharmaceutical Information

Drug Name	Nicotine
Drug ID	BADD_D01564
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status	approved
ATC Code	N07BA01
DrugBank ID	DB00184
KEGG ID	D03365
MeSH ID	D009538
PubChem ID	89594
TTD Drug ID	D0T8GD
NDC Product Code	17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII	6M3C89ZY6R
Synonyms	Nicotine \| Nicotine Bitartrate \| Nicotine Tartrate

Chemical Information

Molecular Formula	C10H14N2
CAS Registry Number	54-11-5; 22083-74-5
SMILES	CN1CCCC1C2=CN=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Cholelithiasis	09.03.01.002	0.000940%		Not Available
Chromaturia	20.02.01.002	0.002131%
Chronic obstructive pulmonary disease	22.03.01.007	0.005516%		Not Available
Cold sweat	23.02.03.002; 08.01.03.024	-	-	Not Available
Completed suicide	19.12.01.001; 08.04.01.010	0.004074%		Not Available
Confusional state	17.02.03.005; 19.13.01.001	-	-
Constipation	07.02.02.001	-	-
Coordination abnormal	17.02.02.004	-	-	Not Available
Coronary artery disease	24.04.04.006; 02.02.01.001	0.000627%		Not Available
Cough	22.02.03.001	0.015295%
Crying	12.02.11.001; 08.01.03.005; 19.04.02.002; 17.02.05.013	0.001379%		Not Available
Cyanosis	23.06.04.005; 02.11.04.004; 24.03.01.007; 22.02.02.007	0.000940%
Cystitis	20.03.02.002; 11.01.14.001	-	-
Delirium	19.13.02.001	-	-
Dental caries	07.09.01.001	0.004137%
Dependence	19.07.06.008	0.003761%		Not Available
Dermatitis	23.03.04.002	-	-	Not Available
Dermatitis bullous	23.03.01.002	-	-
Dermatitis contact	12.03.01.040; 23.03.04.004; 10.01.01.003	0.007773%		Not Available
Diabetes mellitus	14.06.01.001; 05.06.01.001	0.001567%		Not Available
Diarrhoea	07.02.01.001	-	-
Diplopia	17.17.01.005; 06.02.06.002	0.000940%		Not Available
Discomfort	08.01.08.003	-	-	Not Available
Disorientation	19.13.01.002; 17.02.05.015	-	-	Not Available
Disseminated intravascular coagulation	24.01.01.010; 01.01.02.002	0.000940%
Disturbance in attention	19.21.02.002; 17.03.03.001	0.002633%
Dizziness	02.11.04.006; 24.06.02.007; 17.02.05.003	0.017802%
Dizziness postural	24.06.02.008; 17.02.05.004; 02.11.04.008	-	-	Not Available
Drug abuse	19.07.06.010	0.010970%		Not Available
Drug dependence	19.07.06.011	0.046386%		Not Available

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