Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicardipine
Drug ID BADD_D01560
Description A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Indications and Usage Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Marketing Status Prescription; Discontinued
ATC Code C08CA04
DrugBank ID DB00622
KEGG ID D08270
MeSH ID D009529
PubChem ID 4474
TTD Drug ID D0T0KA
NDC Product Code Not Available
Synonyms Nicardipine | Cardene | Vasonase | Antagonil | Cardene SR | Dagan | Flusemide | Lecibral | Lincil | Loxen | Lucenfal | Nicardipine Hydrochloride | Hydrochloride, Nicardipine | Nicardipine LA | LA, Nicardipine | Nicardipino Ratiopharm | Perdipine | Ridene | Y-93 | Y 93 | Y93 | Cardene I.V. | Nicardipino Seid
Chemical Information
Molecular Formula C26H29N3O6
CAS Registry Number 55985-32-5
SMILES CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal pain07.01.05.005--
Haematuria24.07.01.047; 20.02.01.006--
Haemorrhage intracranial17.08.01.008; 24.07.04.003--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia15.05.04.007; 17.05.02.001--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Insomnia19.02.01.002; 17.15.03.002--
Local swelling08.01.03.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervousness19.06.02.003--Not Available
Nocturia20.02.03.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
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