Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nevirapine
Drug ID BADD_D01557
Description A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Indications and Usage For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Marketing Status Prescription; Discontinued
ATC Code J05AG01
DrugBank ID DB00238
KEGG ID D00435
MeSH ID D019829
PubChem ID 4463
TTD Drug ID D0O2EM
NDC Product Code 42571-131; 68554-0044; 65862-932; 31722-505; 0781-5893; 0597-0123; 65162-209; 64380-709; 33342-004; 65862-027; 0378-4050; 0378-4890; 70159-002; 65862-057; 53104-7546; 65862-933; 33342-238; 64220-102; 0597-0047
Synonyms Nevirapine | Nevirapine Hemihydrate | Hemihydrate, Nevirapine | Viramune | BI-RG-587 | BI RG 587 | BIRG587
Chemical Information
Molecular Formula C15H14N4O
CAS Registry Number 129618-40-2
SMILES CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neoplasm malignant16.16.01.0010.012155%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count13.01.06.046--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oligohydramnios18.05.01.0010.003171%Not Available
Opportunistic infection11.01.08.007--Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.006342%
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.0020.012155%Not Available
Paraesthesia17.02.06.005--
Photophobia06.01.01.004; 17.17.02.0060.012155%
Platelet count13.01.04.011--Not Available
Pneumonia22.07.01.003; 11.01.09.0030.009513%Not Available
Premature baby18.04.02.0010.024310%Not Available
Pruritus23.03.12.001--
Pulmonary tuberculosis22.07.06.002; 11.04.01.0030.054698%Not Available
Pyrexia08.05.02.0030.072931%
Rash23.03.13.0010.036465%Not Available
Rash erythematous23.03.06.003--Not Available
Rash generalised23.03.13.0020.018233%Not Available
Rash maculo-papular23.03.13.0040.012155%
Rash papular23.03.13.017--Not Available
Renal failure20.01.03.0050.007927%Not Available
Respiratory distress22.02.01.0120.003171%Not Available
Rhabdomyolysis15.05.05.002--
Sepsis11.01.11.0030.009513%
Sepsis neonatal18.04.12.003; 11.01.11.0070.003171%Not Available
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