Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nelfinavir mesylate
Drug ID BADD_D01550
Description Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Indications and Usage Used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Marketing Status Prescription; Discontinued
ATC Code J05AE04
DrugBank ID DB00220
KEGG ID D00899
MeSH ID D019888
PubChem ID 64142
TTD Drug ID Not Available
NDC Product Code 63010-027; 63010-010
Synonyms Nelfinavir | Viracept | AG 1343 | AG1343 | AG-1343 | Nelfinavir Mesylate | Mesylate, Nelfinavir | Nelfinavir Monomethane Sulfonate | Monomethane Sulfonate, Nelfinavir | Sulfonate, Nelfinavir Monomethane
Chemical Information
Molecular Formula C33H49N3O7S2
CAS Registry Number 159989-65-8
SMILES CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O.CS(=O)(=O )O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceTranscription factor AP-2-alphaP05549T71317Not Available
Insulin resistanceAdiponectinQ15848T15572Not Available
Insulin resistanceLipoprotein lipaseP06858T28692Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoglycaemia05.06.03.001; 14.06.03.001--
Immune system disorder10.02.01.001--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Insulin resistance14.06.02.003; 05.06.02.003--Not Available
Iritis06.04.03.002; 10.02.01.022--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphocyte count13.01.06.037--Not Available
Malaise08.01.01.003--
Metabolic acidosis14.01.01.003--Not Available
Migraine17.14.02.001; 24.03.05.003--Not Available
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myopathy15.05.05.001--Not Available
Myositis15.05.01.001--
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Neutropenia01.02.03.004--Not Available
Neutrophil count13.01.06.046--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Opportunistic infection11.01.08.007--Not Available
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
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