Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone hydrochloride
Drug ID BADD_D01547
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D00819
MeSH ID C051752
PubChem ID 54911
TTD Drug ID D0X7DE
NDC Product Code 0093-1024; 63629-7046; 0093-1025; 0093-7113; 0093-1026; 0093-7178
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H33Cl2N5O2
CAS Registry Number 82752-99-6
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hernia08.01.04.001--Not Available
Hiccups07.01.06.009; 22.02.04.002--
Hostility19.05.01.003--Not Available
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Hypotonia15.05.04.008; 17.05.02.002--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Keratitis06.04.02.002--
Laryngitis22.07.03.001; 11.01.13.001--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased21.03.02.007; 19.08.03.002--
Liver function test abnormal13.03.01.013--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.003--
Menorrhagia21.01.03.002--
Metrorrhagia21.01.01.006--Not Available
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