Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone hydrochloride
Drug ID BADD_D01547
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D00819
MeSH ID C051752
PubChem ID 54911
TTD Drug ID D0X7DE
NDC Product Code 0093-1024; 63629-7046; 0093-1025; 0093-7113; 0093-1026; 0093-7178
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H33Cl2N5O2
CAS Registry Number 82752-99-6
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear pain04.03.01.003--
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002--Not Available
Eczema23.03.04.006--
Ejaculation disorder21.03.01.002--
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Euphoric mood19.04.02.006--
Eye pain06.08.03.002--
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Gait disturbance17.02.05.016; 08.01.02.002--
Galactorrhoea05.03.04.002; 21.05.02.002--Not Available
Gastritis07.08.02.001--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingivitis07.09.03.003; 11.01.04.013--
Glaucoma06.03.01.002--
Glossitis07.14.01.001--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Gynaecomastia05.05.02.003; 21.05.04.003--
Haematocrit decreased13.01.05.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Hallucination19.10.02.002--
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.001--Not Available
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
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