Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Naltrexone
Drug ID BADD_D01527
Description Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Indications and Usage Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
Marketing Status Prescription; Discontinued
ATC Code N07BB04
DrugBank ID DB00704
KEGG ID D05113
MeSH ID D009271
PubChem ID 5360515
TTD Drug ID D0PG8O
NDC Product Code 0406-4605; 65757-300; 16447-0689; 65757-360; 69641-0002; 43798-007; 43798-008; 0406-3940; 43798-006
Synonyms Naltrexone | Antaxone | Trexan | EN-1639A | EN 1639A | EN1639A | ReVia | Nemexin | Nalorex | Naltrexone Hydrochloride | Celupan
Chemical Information
Molecular Formula C20H23NO4
CAS Registry Number 16590-41-3
SMILES C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Ileus paralytic07.02.05.001--Not Available
Immune system disorder10.02.01.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injection site bruising24.07.06.017; 23.03.11.015; 12.07.03.042; 08.02.03.042--Not Available
Injection site haemorrhage24.07.01.010; 12.07.03.005; 08.02.03.005--Not Available
Injection site induration08.02.03.007; 12.07.03.007--Not Available
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Injection site pruritus23.03.12.007; 12.07.03.014; 08.02.03.013--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia19.02.01.002; 17.15.03.002--
Intracranial aneurysm24.02.04.001; 17.08.06.001--Not Available
Irritability19.04.02.013; 08.01.03.011--
Joint stiffness15.01.02.003--Not Available
Laryngeal pain22.02.05.036--
Laryngitis22.07.03.001; 11.01.13.001--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Lymphadenitis01.09.01.001--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 8 Pages