Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin sodium
Drug ID BADD_D01516
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status Prescription; Discontinued
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D00928
MeSH ID D009254
PubChem ID 23667630
TTD Drug ID D0A0JH
NDC Product Code 63323-328; 55150-123; 0781-9224; 55150-122; 55150-124; 52946-0922; 25021-140; 25021-139; 63323-327; 52946-0819; 70860-119; 25021-141; 70860-116; 61126-704; 0781-9225; 70860-117; 0781-3129; 0781-3128
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H21N2NaO5S
CAS Registry Number 985-16-0
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Bronchospasm10.01.03.012; 22.03.01.004--
Circulatory collapse24.06.02.001--Not Available
Death08.04.01.001--
Diarrhoea07.02.01.001--
Drug hypersensitivity10.01.01.001--Not Available
Extravasation08.01.03.008--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hypotension24.06.03.002--
Laryngospasm22.04.02.002--
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Neutropenia01.02.03.004--Not Available
Pain08.01.08.004--
Phlebitis24.05.03.001; 12.02.01.002--
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.003--
Renal tubular disorder20.05.03.004--Not Available
Skin exfoliation23.03.07.003--Not Available
Stomatitis07.05.06.005--
Swelling08.01.03.015--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tongue discolouration07.14.02.006--Not Available
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