Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Muromonab-cd3
Drug ID BADD_D01506
Description Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Indications and Usage For treatment of organ transplant recipients, prevention of organ rejection
Marketing Status Not Available
ATC Code L04AA02
DrugBank ID DB00075
KEGG ID D05092
MeSH ID D016853
PubChem ID Not Available
TTD Drug ID D05GVQ
NDC Product Code Not Available
Synonyms Muromonab-CD3 | Muromonab CD3 | OKT3 | Monoclonal Antibody OKT3 | Orthoclone OKT3
Chemical Information
Molecular Formula Not Available
CAS Registry Number 140608-64-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Serum sickness12.02.08.004; 10.01.03.004--
Shock24.06.02.002--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Splenomegaly01.09.02.001--Not Available
Status epilepticus17.12.03.005--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stupor19.02.05.004; 17.02.04.007--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombosis24.01.01.006--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Tremor17.01.06.002--
Urinary casts13.13.02.014--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vasculitis24.05.02.001; 10.02.02.006--
Venous thrombosis24.01.01.008--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Tubulointerstitial nephritis20.05.02.002--Not Available
Intracardiac thrombus02.01.01.007; 24.01.05.003--Not Available
Hypoacusis04.02.01.006--
Brain oedema12.01.10.010; 17.07.02.003--
Quadriparesis17.01.04.012--Not Available
Left ventricular dysfunction02.04.02.011--
Cytokine release syndrome10.02.01.010--
Haemodynamic instability24.03.02.006--Not Available
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