Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Muromonab-cd3
Drug ID BADD_D01506
Description Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Indications and Usage For treatment of organ transplant recipients, prevention of organ rejection
Marketing Status Not Available
ATC Code L04AA02
DrugBank ID DB00075
KEGG ID D05092
MeSH ID D016853
PubChem ID Not Available
TTD Drug ID D05GVQ
NDC Product Code Not Available
Synonyms Muromonab-CD3 | Muromonab CD3 | OKT3 | Monoclonal Antibody OKT3 | Orthoclone OKT3
Chemical Information
Molecular Formula Not Available
CAS Registry Number 140608-64-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial infarction02.02.02.007; 24.04.04.009--
Myoclonus17.02.05.008--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oliguria20.01.03.004--Not Available
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Paranoia19.05.01.005--Not Available
Paraplegia17.01.04.007--Not Available
Paresis17.01.04.008--Not Available
Photophobia17.17.02.006; 06.01.01.004--
Plasma cell myeloma16.23.02.004; 01.14.02.004--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonitis22.01.01.006--
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pulmonary thrombosis24.01.06.002; 22.06.02.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retinal vasculitis10.02.02.021; 06.04.06.011--Not Available
Seizure17.12.03.001--
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