Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Morphine
Drug ID BADD_D01498
Description Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.[L12114]
Indications and Usage For the relief and treatment of severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AA01
DrugBank ID DB00295
KEGG ID D08233
MeSH ID D009020
PubChem ID 5288826
TTD Drug ID D0WE3O
NDC Product Code 42799-217
Synonyms Morphine | Morphia | Morphine Chloride | Chloride, Morphine | Morphine Sulfate | Sulfate, Morphine | SDZ 202-250 | SDZ 202 250 | SDZ 202250 | SDZ202-250 | SDZ202 250 | SDZ202250 | Morphine Sulfate (2:1), Pentahydrate | MS Contin | Contin, MS | Oramorph SR | Duramorph | Morphine Sulfate (2:1), Anhydrous
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 57-27-2
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cardiac arrhythmiasMu-type opioid receptorP35372T4776825806604
Cardiac arrhythmiasMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
HyperpathiaMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
HyperpathiaTranscription factor JunP05412T6908525806604
HyperpathiaMu-type opioid receptorP35372T4776825806604
HyperpathiaMitogen-activated protein kinase 8P45983T4009725806604
HyperpathiaProtein kinase C alpha typeP17252T1280825806604
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hiccups22.02.04.002; 07.01.06.0090.001171%
Hydrocephalus17.07.01.0010.001406%
Hydronephrosis20.01.05.001--Not Available
Hyperaesthesia17.02.06.0040.004686%Not Available
Hypercapnia22.02.02.002; 14.01.04.0010.001874%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.0040.011715%
Hyperkalaemia14.05.03.001--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.001874%
Hypertension24.08.02.001--
Hyperthermia12.05.01.002; 08.05.01.0010.000428%Not Available
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypopnoea22.02.01.0210.002109%Not Available
Hyporeflexia17.02.01.0030.000469%
Hypotension24.06.03.0020.024133%
Hypothermia12.05.03.001; 08.05.01.0030.002812%
Hypotonia17.05.02.002; 15.05.04.0080.001406%Not Available
Hypoventilation22.02.01.0070.000937%Not Available
Hypovolaemic shock24.06.02.017--Not Available
Hypoxia22.02.02.0030.007263%
Ileus07.13.01.0010.001406%
Ileus paralytic07.02.05.0010.001171%Not Available
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