Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minoxidil
Drug ID BADD_D01473
Description A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Indications and Usage For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.
Marketing Status Prescription; OTC; Discontinued
ATC Code C02DC01; D11AX01
DrugBank ID DB00350
KEGG ID D00418
MeSH ID D008914
PubChem ID 4201
TTD Drug ID D0Y2CJ
NDC Product Code 51927-2885; 37808-833; 51672-2129; 63981-798; 50383-001; 63981-032; 42291-619; 41250-749; 82269-607; 38779-0574; 49035-202; 69282-002; 43353-342; 40700-0008; 64162-0209; 69968-0030; 25280-007; 71176-781; 59640-000; 21130-819; 41250-428; 42291-618; 11673-919; 0113-1129; 68391-294; 69113-129; 11673-317; 71730-294; 56062-202; 49884-256; 56062-798; 41250-294; 0363-2294; 63486-015; 0591-5643; 0363-2798; 76003-0748; 57483-542; 11822-0202; 51552-0536; 0591-5642; 66219-0004; 69282-001; 71730-798; 49035-294; 68196-032; 51326-160; 11822-0129; 0113-0294; 72764-001; 68196-469; 63629-2232; 79481-0070; 59779-294; 41250-798; 41163-798; 21130-750; 37808-798; 57483-535; 72288-202; 63629-2230; 0009-5056; 63940-032; 56062-294; 30142-798; 68016-382; 71205-490; 68084-204; 59779-202; 46204-0159; 82157-100; 71713-092; 68981-036; 0113-0798; 51552-1334; 0009-5230; 57483-530; 71713-093; 11822-0702; 70550-605; 30142-632; 72484-095; 63940-491; 49035-746; 79974-201; 17337-0027; 0113-7294; 62991-1105; 81653-002; 73277-002; 54236-020; 0113-7202; 80855-201; 37808-202; 11673-431; 82157-200; 11822-0606; 69113-128; 0113-7798; 79572-022; 67438-015; 0363-1129; 0363-0703; 73277-001; 63629-1085; 71290-813; 79903-072; 0113-7129; 65121-101; 0363-7202; 56062-322; 63940-202; 46144-342; 25280-006; 69423-586; 51672-2128; 68196-823; 63629-1086; 11673-798; 63934-007; 71730-202; 11673-189; 63940-385; 0363-0032; 49035-798; 63981-380; 67438-020; 69968-0031; 0113-1032; 63629-2231; 69842-599; 49452-4780; 70550-503; 21130-273; 11673-632; 69968-0089; 72882-094; 53489-386; 11673-707; 65121-102; 68084-205; 72288-294; 37808-404; 11822-1033; 49539-001; 71713-091; 0472-0066; 80813-0022; 65121-562; 69968-0090; 57483-540; 63940-582; 0113-7032; 41250-202; 55301-094; 72764-002; 69842-797; 11822-0798; 63486-016; 49884-257; 71730-129; 11673-382; 21130-163; 59779-798; 53489-387; 30142-719; 11509-0798; 51326-161; 69842-598; 81653-001; 69423-587; 63981-294; 49035-905; 71724-400; 72288-129; 30142-294; 68016-006
Synonyms Minoxidil | Rogaine | Regaine | U 10858 | Loniten
Chemical Information
Molecular Formula C9H15N5O
CAS Registry Number 38304-91-5
SMILES C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Electrocardiogram ST segment depression13.14.05.0050.009645%Not Available
Erythema23.03.06.0010.009645%Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye irritation06.04.05.0030.003215%Not Available
Eye swelling06.08.03.0030.003215%Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.004823%
Feeling hot08.01.09.0090.003215%Not Available
Fluid overload14.05.06.001; 02.05.04.0040.004823%Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.008038%
Folliculitis23.09.04.007; 11.01.12.0180.004823%
Gastrointestinal disorder07.11.01.001--Not Available
Gynaecomastia21.05.04.003; 05.05.02.0030.004823%
Hair colour changes23.02.06.0010.003215%
Hair disorder23.02.06.003--Not Available
Hair growth abnormal23.02.06.0060.006430%Not Available
Hair texture abnormal23.02.06.0040.009645%
Headache17.14.01.0010.014468%
Heart rate increased13.14.04.0020.003215%Not Available
Hypersensitivity10.01.03.0030.004823%
Hypertension24.08.02.0010.006430%
Hypertrichosis23.02.04.0020.041796%
Hypotension24.06.03.0020.032150%
Irritability19.04.02.013; 08.01.03.0110.003215%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.004823%
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Meningioma17.20.01.005; 16.30.01.0050.004823%Not Available
Myocardial infarction24.04.04.009; 02.02.02.0070.004823%
Nausea07.01.07.0010.014468%
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