Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline hydrochloride
Drug ID BADD_D01472
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D00850
MeSH ID D008911
PubChem ID 54685925
TTD Drug ID D08LTU
NDC Product Code 17158-0900; 67877-438; 70771-1426; 71335-1045; 63629-9209; 60687-336; 67877-436; 73309-310; 68071-4163; 68788-8097; 47781-545; 64380-154; 68180-380; 67877-437; 65862-210; 68071-5262; 70771-1155; 71403-101; 44657-0081; 65862-209; 69489-123; 63187-036; 63629-9214; 59651-338; 71335-0570; 61919-595; 71335-0682; 53002-2880; 65862-557; 67877-576; 61919-560; 70934-097; 53002-2210; 68788-7052; 68682-467; 59651-337; 71205-086; 57664-855; 0904-6888; 63629-9212; 72143-221; 63629-9215; 58159-085; 68382-318; 0591-5695; 59651-339; 57664-851; 65862-884; 70518-2943; 0591-3153; 55111-638; 68382-535; 44657-0051; 43353-172; 63629-9211; 68382-552; 50090-3016; 99207-465; 63629-2796; 65862-558; 71205-511; 70771-1428; 71403-102; 0781-5386; 67877-578; 65862-555; 68682-466; 68180-381; 67296-1181; 99207-466; 68180-379; 68382-316; 0115-9936; 63629-9213; 47781-546; 42546-774; 68180-460; 55289-201; 70771-1156; 68382-533; 13668-486; 13668-483; 16714-107; 16714-108; 0781-5387; 57664-852; 65862-885; 42291-620; 72143-222; 16714-109; 0591-5694; 13668-482; 63629-6422; 69489-121; 13668-484; 68382-551; 65862-211; 70934-041; 0115-9935; 57664-856; 16714-106; 68071-4216; 67877-643; 68225-074; 73402-112; 57664-854; 71205-272; 72143-223; 65862-883; 68682-468; 43353-105; 58118-0484; 69489-122; 99207-467; 13668-487; 67877-577; 47781-544; 99207-463; 68382-531; 16714-104; 55111-637; 58623-0133; 50090-2339; 70771-1138; 63187-850; 61919-337; 70518-1336; 68071-2311; 99207-464; 50090-5710; 61919-845; 65862-556; 0781-5385; 65976-100; 16714-103; 55111-639; 42546-771; 57664-853; 70771-1157; 71335-1123; 71335-0046; 65862-554; 42546-777; 70934-042; 68382-317; 55289-202; 50909-9201; 70771-1427; 50909-9101; 55700-415; 55700-649; 63629-9210; 64380-156; 51927-2197; 50090-3644; 61919-270; 43063-736; 67877-644; 50090-0632; 68071-2225; 63629-9208; 16714-102; 50090-3697; 70842-160; 63187-450; 71335-1237; 16714-105; 13668-485; 64380-155; 70771-1167
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H28ClN3O7
CAS Registry Number 13614-98-7
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Balanoposthitis21.09.03.001--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Biopsy thyroid gland abnormal13.10.08.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysphagia07.01.06.003--
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.017--Not Available
Fontanelle bulging18.04.04.001; 17.02.05.006--Not Available
Glossitis07.14.01.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.003--
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Mood altered19.04.02.007--Not Available
Myalgia15.05.02.001--
Pancreatitis07.18.01.001--
Pericarditis02.06.02.001--
Photosensitivity reaction23.03.09.003--
Pruritus23.03.12.001--
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