Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline
Drug ID BADD_D01470
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D05045
MeSH ID D008911
PubChem ID 54675783
TTD Drug ID D08LTU
NDC Product Code 42291-591; 42291-589; 69489-201; 72356-101; 49884-512; 72356-103; 63629-2228; 49884-513; 63629-2229; 49884-511
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H27N3O7
CAS Registry Number 10118-90-8
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not Available1421660; 3224399; 1814842
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intracranial pressure increased17.07.02.0020.005437%Not Available
Irritable bowel syndrome19.24.01.003; 07.02.04.0030.001812%Not Available
Jaundice23.03.03.030; 01.06.04.004; 09.01.01.0040.003883%Not Available
Joint stiffness15.01.02.0030.001553%Not Available
Joint swelling15.01.02.0040.003366%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.0020.002848%
Leukopenia01.02.02.001--Not Available
Linear IgA disease23.03.01.015; 10.04.02.0060.000518%Not Available
Lip discolouration07.05.05.009--Not Available
Lip dry07.06.01.0030.001294%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.001294%Not Available
Livedo reticularis24.03.04.003; 23.06.05.0010.001812%Not Available
Liver function test abnormal13.03.01.0130.001812%Not Available
Lividity23.06.05.0090.000518%Not Available
Local swelling08.01.03.0130.001036%Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.001--Not Available
Lung infiltration22.01.02.0040.000518%Not Available
Lymphadenopathy01.09.01.0020.006472%Not Available
Lymphocytosis01.02.01.0030.000777%Not Available
Macule23.03.03.0370.000777%Not Available
Malaise08.01.01.003--
Melanocytic naevus23.10.01.007; 16.26.01.0070.000338%Not Available
Melanosis23.05.01.0040.000270%Not Available
Meningitis aseptic17.06.03.002; 11.01.03.0020.000777%Not Available
Metabolic acidosis14.01.01.0030.000777%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mitral valve incompetence02.07.01.0020.001036%Not Available
Mouth ulceration07.05.06.0040.000518%Not Available
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