Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline
Drug ID BADD_D01470
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D05045
MeSH ID D008911
PubChem ID 54675783
TTD Drug ID D08LTU
NDC Product Code 42291-591; 42291-589; 69489-201; 72356-101; 49884-512; 72356-103; 63629-2228; 49884-513; 63629-2229; 49884-511
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H27N3O7
CAS Registry Number 10118-90-8
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not Available1421660; 3224399; 1814842
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cholestatic liver injury09.01.07.0160.000518%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.004--
Brain stem stroke24.04.06.024; 17.08.01.0330.001812%Not Available
Acute kidney injury20.01.03.0160.005696%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.018640%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.027184%Not Available
Candida infection11.03.03.021--
Multiple organ dysfunction syndrome08.01.03.0570.001621%
Liver function test increased13.03.01.044--Not Available
Antiphospholipid syndrome24.01.01.029; 18.02.04.002; 10.04.01.009; 01.01.02.0160.001553%Not Available
Catabolic state14.11.01.0340.000518%Not Available
Cervical myelopathy17.10.02.0050.001553%Not Available
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.001294%Not Available
Encephalomyelitis17.06.05.003; 11.01.03.0120.000777%
Lateral medullary syndrome17.08.01.055; 24.04.06.0380.001294%Not Available
Mononeuropathy multiplex17.09.02.0120.006472%Not Available
Normal pressure hydrocephalus17.07.01.0020.002848%Not Available
Post inflammatory pigmentation change23.05.03.0020.001036%Not Available
Renal arteritis24.05.01.007; 20.01.07.0130.000518%Not Available
Smooth muscle antibody positive13.06.01.0200.000518%Not Available
Symblepharon06.06.02.0120.001036%Not Available
Testicular infarction24.04.12.003; 21.13.01.0090.001812%Not Available
Thyroiditis acute05.02.04.0040.002589%Not Available
Antiphospholipid antibodies positive13.06.01.0160.001553%Not Available
Anti-neutrophil cytoplasmic antibody positive vasculitis24.05.02.016; 10.02.02.0230.002589%Not Available
Eosinophilic pneumonia chronic01.02.04.017; 22.01.01.0200.000777%Not Available
Brain natriuretic peptide increased13.02.04.0110.000518%Not Available
Histone antibody positive13.06.01.0180.001036%Not Available
General physical condition abnormal13.15.01.0400.000518%Not Available
Antineutrophil cytoplasmic antibody increased13.06.01.0150.001294%Not Available
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