Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Midodrine
Drug ID BADD_D01461
Description An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Indications and Usage For the treatment of symptomatic orthostatic hypotension (OH).
Marketing Status Prescription; Discontinued
ATC Code C01CA17
DrugBank ID DB00211
KEGG ID D08220
MeSH ID D008879
PubChem ID 4195
TTD Drug ID D02XJY
NDC Product Code 0615-8358
Synonyms Midodrine | Midodrin | Midodrine Hydrochloride | Midodrine Monohydrochloride | Monohydrochloride, Midodrine | ProAmatine | Amatine | ST-1085 | ST 1085 | ST1085 | Gutron | Midon
Chemical Information
Molecular Formula C12H18N2O4
CAS Registry Number 42794-76-3
SMILES COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability19.04.02.013; 08.01.03.011--
Micturition urgency20.02.02.006--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Piloerection23.02.06.005--Not Available
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Retinal vein occlusion24.01.07.006; 06.10.01.010--Not Available
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 10.01.03.020; 11.07.01.005--
Stomatitis07.05.06.005--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Vasodilation procedure25.03.01.001--Not Available
Angiopathy24.03.02.007--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Cardiac disorder02.01.01.003--Not Available
Mental disorder19.07.01.002--Not Available
Hepatobiliary disease09.01.08.003--Not Available
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