Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metyrosine
Drug ID BADD_D01451
Description An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)
Indications and Usage For use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma.
Marketing Status Prescription
ATC Code C02KB01
DrugBank ID DB00765
KEGG ID D00762
MeSH ID D019805
PubChem ID 441350
TTD Drug ID D0B3QM
NDC Product Code 73223-007; 25010-305; 69238-1621; 68682-310; 67763-129; 68022-7056; 71554-026; 69575-4022
Synonyms alpha-Methyltyrosine | alpha Methyltyrosine | alpha-Methyl-para-tyrosine | alpha Methyl para tyrosine | alpha-MPT | alpha MPT | alpha-Methyl-p-tyrosine | alpha Methyl p tyrosine | Metyrosine | alpha-Methyltyrosine, (L)-Isomer | Metirosine | Racemetirosine | alpha-Methyltyrosine, (D,L)-Isomer | alpha-Methyltyrosine, (+,-)-Isomer | DL-Tyrosine, alpha-methyl- | alpha-methyl- DL-Tyrosine | alpha-Methyltyrosine Hydrochloride | Hydrochloride, alpha-Methyltyrosine | alpha Methyltyrosine Hydrochloride | Demser
Chemical Information
Molecular Formula C10H13NO3
CAS Registry Number 672-87-7
SMILES CC(CC1=CC=C(C=C1)O)(C(=O)O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aptyalism07.06.01.001--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Breast swelling21.05.05.008--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Crystalluria20.02.01.003--Not Available
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002--Not Available
Drooling17.02.05.005--Not Available
Dry mouth07.06.01.002--
Dysuria20.02.02.002--
Ejaculation disorder21.03.01.002--
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gastrointestinal pain07.01.05.005--
Haematuria24.07.01.047; 20.02.01.006--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Insomnia19.02.01.002; 17.15.03.002--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.007--
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