Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol
Drug ID BADD_D01445
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D02358
MeSH ID D008790
PubChem ID 4171
TTD Drug ID D0I2MK
NDC Product Code 0615-8422; 71205-003; 46708-291; 62332-113; 46708-292; 62332-114; 0615-8423; 62207-970; 62332-112; 65977-0117; 0615-8421; 46708-290
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C15H25NO3
CAS Registry Number 51384-51-1
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.0020.000047%
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000031%
Blood potassium decreased13.11.01.010--Not Available
Blood potassium increased13.11.01.0110.000047%Not Available
Blood pressure abnormal13.14.03.0010.000093%Not Available
Blood pressure decreased13.14.03.0020.000357%Not Available
Blood pressure diastolic decreased13.14.03.0030.000031%Not Available
Blood pressure fluctuation24.06.01.0020.000031%Not Available
Blood pressure increased13.14.03.0050.000419%Not Available
Blood pressure systolic13.14.03.012--Not Available
Blood pressure systolic decreased13.14.03.0070.000093%Not Available
Blood pressure systolic increased13.14.03.0060.000062%Not Available
Blood sodium decreased13.11.01.0120.000031%Not Available
Blood triglycerides increased13.12.03.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bowen's disease23.08.02.004; 16.03.02.0040.000062%Not Available
Bradycardia02.03.02.0020.004248%Not Available
Bradypnoea22.02.01.0020.000031%Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.000155%
Bundle branch block right02.03.01.0110.000047%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.0010.000291%
Cardiac failure02.05.01.0010.000113%
Cardiac failure acute02.05.01.0050.000024%Not Available
Cardiac failure congestive02.05.01.002--Not Available
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 21 Pages