Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Marketing Status Prescription; Discontinued
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 70165-200; 68968-5554; 0406-7654; 0781-2361; 0781-2364; 68968-5553; 68968-5555; 70165-100; 70165-300; 68968-5552; 0781-2363; 0781-2362
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityBeta-2 adrenergic receptorP07550T525229187524; 7913199; 8382844; 6147001; 1957308; 7716792; 12616289
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Impulsive behaviour19.18.01.0010.001561%Not Available
Jaw fracture12.04.05.001; 15.08.02.0060.000275%Not Available
Non-alcoholic fatty liver14.08.04.023; 09.01.07.0340.000184%Not Available
Obstruction gastric07.13.04.0020.000184%
Open angle glaucoma06.03.01.0040.000367%Not Available
Optic disc haemorrhage24.07.05.014; 06.07.03.0050.000048%Not Available
Pancreatitis relapsing07.18.01.0110.000184%Not Available
Persecutory delusion19.10.01.0070.000275%Not Available
Respiratory rate increased13.15.01.0040.000275%Not Available
Systemic sclerosis24.03.03.041; 23.03.02.021; 10.04.07.006; 15.06.01.019; 07.11.02.0080.000096%Not Available
Temporal lobe epilepsy17.12.02.0040.000184%Not Available
Univentricular heart03.07.02.007; 02.04.02.0360.000184%Not Available
Violence-related symptom19.05.01.0220.000184%Not Available
Wolff-Parkinson-White syndrome02.03.01.0160.000275%Not Available
Groin abscess15.03.02.016; 11.01.08.0540.000184%Not Available
Oppositional defiant disorder19.21.04.0030.000184%Not Available
Body height below normal13.15.01.0350.000367%Not Available
Onychophagia23.02.05.027; 19.18.01.0080.000459%Not Available
Factor V Leiden mutation01.01.02.019; 03.15.01.0080.000184%Not Available
Negative thoughts19.15.02.0120.000184%Not Available
General physical condition abnormal13.15.01.0400.000184%Not Available
Insulin-like growth factor increased13.10.10.0040.000184%Not Available
Urine amphetamine negative13.17.02.0160.000551%Not Available
Intelligence test abnormal13.15.01.0430.000184%Not Available
Communication disorder19.19.01.0080.000367%Not Available
Disturbance in social behaviour19.05.01.0180.002754%Not Available
Heart injury12.01.11.003; 02.01.01.0100.000275%Not Available
Amphetamines positive13.17.02.0090.000643%Not Available
Tachyphrenia17.03.03.007; 19.10.03.0100.000184%Not Available
Excessive eye blinking17.17.02.010; 06.05.01.0040.000275%Not Available
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