Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mepivacaine
Drug ID BADD_D01387
Description A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Indications and Usage For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Marketing Status Prescription; Discontinued
ATC Code N01BB03
DrugBank ID DB00961
KEGG ID D08181
MeSH ID D008619
PubChem ID 4062
TTD Drug ID D0WO8W
NDC Product Code 52932-0745
Synonyms Mepivacaine | Mepivacaina Braun | Isogaine | Meaverin | Mecain | Mepihexal | Mepivacain-Injektopas | Mepivacain Injektopas | Mepivacaine Hydrochloride | Mepivacaine Monohydrochloride | Mepivastesin | Polocaine | Scandinibsa | Scandonest | Scandicain | Scandicaine | Carbocaine | Carbocaïne | Isocaine
Chemical Information
Molecular Formula C15H22N2O
CAS Registry Number 96-88-8
SMILES CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.0030.001182%
Hypertension24.08.02.0010.001576%
Hypotension24.06.03.002--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Loss of consciousness17.02.04.0040.001182%Not Available
Malaise08.01.01.0030.001576%
Meningism17.02.05.007--
Meningitis11.01.03.001; 17.06.03.001--
Nausea07.01.07.0010.001182%
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oral discomfort07.05.05.0010.001182%Not Available
Pain08.01.08.0040.001182%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.000788%Not Available
Paraesthesia17.02.06.0050.001182%
Paralysis17.01.04.004--Not Available
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.000788%
Pruritus23.03.12.001--
Respiratory arrest22.02.01.0090.000411%Not Available
Respiratory paralysis22.02.06.003; 17.01.04.010--Not Available
Retinal artery occlusion24.01.07.003; 06.10.01.0050.001576%Not Available
Seizure17.12.03.0010.001576%
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.0100.000788%
Sneezing22.02.05.011--
Somnolence19.02.05.003; 17.02.04.0060.000788%
Spinal anaesthesia25.01.03.001--Not Available
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.001576%
Tachycardia02.03.02.0070.001182%Not Available
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