Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Meloxicam
Drug ID BADD_D01374
Description Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis.[A190189] With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201]
Indications and Usage For symptomatic treatment of arthritis and osteoarthritis.
Marketing Status Prescription; Discontinued
ATC Code M01AC06
DrugBank ID DB00814
KEGG ID D00969
MeSH ID D000077239
PubChem ID 54677470
TTD Drug ID D0G7FJ
NDC Product Code 61919-469; 38779-2746; 67296-1317; 29300-125; 68788-7904; 63629-2020; 71610-583; 0615-8124; 70518-1828; 65841-051; 43063-396; 43063-401; 72865-138; 69344-205; 80425-0043; 61919-434; 71610-580; 68071-4987; 71610-544; 42708-093; 65862-097; 70518-3023; 43063-395; 50090-5339; 51552-1377; 50436-1125; 17373-1157; 56125-750; 70954-077; 70859-007; 69344-206; 17373-1158; 72969-045; 60760-419; 60760-448; 43353-979; 80425-0045; 51869-0008; 76282-153; 65841-050; 70934-010; 60592-994; 72865-137; 59349-0003; 53002-1537; 50090-5861; 0615-8040; 53747-006; 68071-1919; 53069-0790; 50090-0986; 67296-1817; 50436-1124; 68071-3030; 71335-0406; 51407-610; 45865-360; 68382-050; 35356-808; 69097-159; 67296-0583; 54458-964; 50090-5340; 68180-502; 51407-611; 61442-126; 50090-0985; 61442-127; 71205-923; 43353-127; 68382-051; 80425-0041; 71518-001; 67296-0823; 68225-112; 16571-776; 50268-526; 51869-0007; 52119-003; 71610-542; 76282-152; 55289-618; 67296-1250; 49452-4402; 71335-1888; 68981-032; 60760-404; 70954-076; 42708-007; 68462-141; 68180-501; 65862-098; 70518-0039; 53002-2535; 71205-924; 54458-965; 80425-0042; 53104-7574; 68071-1993; 50090-4896; 70518-0200; 43353-038; 0395-8154; 68071-1994; 68071-2184; 60687-199; 53002-1535; 80425-0083; 65862-223; 68180-189; 68788-1701; 0597-0029; 70518-2631; 0597-0030; 64380-715; 68788-9418; 50268-525; 71610-380; 68462-140; 63629-3328; 29300-124; 69097-158; 76420-043; 51655-731; 63629-2019; 58118-1158; 68788-7726; 53002-2537; 71335-1956; 63629-7966; 64380-716; 71335-1618; 65841-004; 63187-082; 62938-0026; 63187-083; 71610-516; 68180-188; 16571-777; 70518-1299; 51927-0032; 70518-0031; 49999-869; 80425-0044; 76420-039; 51655-577; 63629-3248; 55289-272; 70518-0171; 22365-116; 58624-0430
Synonyms Meloxicam | Miloxicam | Parocin | Mobic | Mobicox | Mobec | Masflex | Movicox | Reumoxicam | Uticox | Movalis
Chemical Information
Molecular Formula C14H13N3O4S2
CAS Registry Number 71125-38-7
SMILES CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
White blood cell count increased13.01.06.0130.000073%Not Available
Mental status changes19.07.01.0010.000073%Not Available
Tubulointerstitial nephritis20.05.02.0020.000220%Not Available
Musculoskeletal disorder15.03.01.0040.000073%Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Localised oedema02.05.04.006; 14.05.06.009; 08.01.07.0110.000073%
Shock haemorrhagic24.06.02.014; 14.05.05.0030.000019%Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.0010.000147%
Deep vein thrombosis24.01.02.0030.000147%Not Available
Malignant neoplasm progression16.16.01.005--Not Available
Pruritus generalised23.03.12.0030.000073%Not Available
Epigastric discomfort07.01.02.0040.000073%Not Available
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.0010.000073%Not Available
Transaminases increased13.03.01.0150.000110%Not Available
Haemorrhage24.07.01.0020.000367%Not Available
Gastrointestinal ulcer haemorrhage24.07.02.023; 07.04.04.0060.000073%Not Available
Gastric disorder07.11.01.0030.000147%Not Available
Colitis microscopic07.08.01.0110.000220%Not Available
Drug resistance08.06.01.0050.000105%Not Available
Hepatic enzyme increased13.03.01.0190.000073%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Gastrointestinal injury12.01.02.002; 07.11.01.0060.000073%Not Available
Inflammation08.01.05.0070.000147%Not Available
Amnestic disorder19.20.05.001; 17.03.02.0070.000110%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Disease progression08.01.03.0380.000105%
Drug intolerance08.06.01.0130.000147%Not Available
Renal impairment20.01.03.0100.000220%Not Available
Haemorrhagic diathesis24.07.01.020; 01.01.03.0030.000073%Not Available
Intestinal diaphragm disease07.13.01.0110.000440%Not Available
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