Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Megestrol
Drug ID BADD_D01371
Description 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Indications and Usage For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Marketing Status Not Available
ATC Code G03AC05; G03DB02; L02AB01
DrugBank ID DB00351
KEGG ID D08167
MeSH ID D008535
PubChem ID 19090
TTD Drug ID D04GJN
NDC Product Code 46439-8722; 68094-250; 0555-0607; 17856-0907; 49884-230; 49884-907; 50383-859; 63629-2220; 63739-549; 64380-158; 66689-020; 81646-120; 51991-313; 77044-5047; 0121-4776; 49884-290; 63629-7631; 71205-943; 0009-5030; 24979-041; 60429-433; 63629-2221; 0555-0606; 43744-363; 51927-1670; 63592-0109; 0904-3571; 49884-289; 63629-2219; 0904-7072; 0121-0945; 60432-126; 64380-159; 68094-361; 72969-102; 55154-5776
Synonyms Megestrol | 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione | Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
Chemical Information
Molecular Formula C22H30O3
CAS Registry Number 3562-63-8
SMILES CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hepatomegaly09.01.05.001--Not Available
Herpes virus infection11.05.02.008--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lethargy19.04.04.004; 08.01.01.008; 17.02.04.003--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Lung disorder22.02.07.001--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Metrorrhagia21.01.01.006--Not Available
Mood swings19.04.03.001--Not Available
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
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