Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Meclizine
Drug ID BADD_D01361
Description Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects.[L6760] Commonly marketed under the brand name Antivert in the U.S., meclizine is available as oral tablets.
Indications and Usage For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Marketing Status Prescription; Discontinued
ATC Code R06AE05
DrugBank ID DB00737
KEGG ID D08163
MeSH ID D008468
PubChem ID 4034
TTD Drug ID D0T1XW
NDC Product Code 67763-116; 50268-522; 71335-0732; 71554-010; 0615-8303; 51927-0043; 65162-441; 0904-6516; 70518-1402; 61919-301
Synonyms Meclizine | Parachloramine | Meclozine | Antivert | Bonamine | Bonine | Chiclida | Histametizyn | Meclizine Hydrochloride | Hydrochloride, Meclizine | Meclizine Dihydrochloride | Dihydrochloride, Meclizine | Meclizine Monohydrochloride | Monohydrochloride, Meclizine | Ru-Vert-M | Ru Vert M | Agyrax | D-Vert | D Vert | DVert
Chemical Information
Molecular Formula C25H27ClN2
CAS Registry Number 569-65-3
SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Asthenia08.01.01.001--Not Available
Dry mouth07.06.01.002--
Fatigue08.01.01.002--
Headache17.14.01.001--
Somnolence19.02.05.003; 17.02.04.006--
Vision blurred17.17.01.010; 06.02.06.007--
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