Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maraviroc
Drug ID BADD_D01352
Description Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Indications and Usage For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Marketing Status Prescription
ATC Code J05AX09
DrugBank ID DB04835
KEGG ID D06670
MeSH ID D000077592
PubChem ID 3002977
TTD Drug ID D0NR6S
NDC Product Code 69037-0062; 49702-223; 50923-0414; 12828-0091; 49702-260; 49702-235; 69037-0061; 31722-579; 49702-233; 31722-580; 68554-0040; 49702-237; 76072-1019; 49702-224
Synonyms Maraviroc | 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide | Selzentry | UK-427,857 | UK 427,857 | UK427,857 | UK-427857 | UK 427857 | UK427857
Chemical Information
Molecular Formula C29H41F2N5O
CAS Registry Number 376348-65-1
SMILES CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory disorder22.02.07.002--Not Available
Respiratory distress22.02.01.012--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retinal tear12.01.04.014; 06.09.03.010--
Rhabdomyolysis15.05.05.002--
Rhinitis11.01.13.004; 22.07.03.006--
Seborrhoeic keratosis23.10.01.008; 16.26.01.008--Not Available
Seizure17.12.03.001--
Sensory disturbance17.02.07.006--Not Available
Septic shock24.06.02.011; 11.01.11.0040.000377%Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.001--Not Available
Small intestinal obstruction07.13.06.001--
Squamous cell carcinoma16.16.01.002--Not Available
Squamous cell carcinoma of skin23.08.02.005; 16.03.02.005--Not Available
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.03.020; 23.03.01.007--
Stomatitis07.05.06.005--
Suicidal ideation19.12.01.003--
Sweat gland tumour23.10.01.009; 16.26.01.009--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tetany15.05.03.013; 14.04.01.005; 05.04.02.003--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tracheobronchitis22.07.03.010; 11.01.13.008--Not Available
Tremor17.01.06.002--
Ulcer08.03.06.001--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
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