Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maraviroc
Drug ID BADD_D01352
Description Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Indications and Usage For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Marketing Status Prescription
ATC Code J05AX09
DrugBank ID DB04835
KEGG ID D06670
MeSH ID D000077592
PubChem ID 3002977
TTD Drug ID D0NR6S
NDC Product Code 69037-0062; 49702-223; 50923-0414; 12828-0091; 49702-260; 49702-235; 69037-0061; 31722-579; 49702-233; 31722-580; 68554-0040; 49702-237; 76072-1019; 49702-224
Synonyms Maraviroc | 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide | Selzentry | UK-427,857 | UK 427,857 | UK427,857 | UK-427857 | UK 427857 | UK427857
Chemical Information
Molecular Formula C29H41F2N5O
CAS Registry Number 376348-65-1
SMILES CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oliguria20.01.03.004--Not Available
Opportunistic infection11.01.08.007--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.0050.001447%
Parkinsonism17.01.05.003--Not Available
Pathogen resistance11.01.08.0490.000566%Not Available
Peripheral ischaemia24.04.03.0020.001447%
Petit mal epilepsy17.12.04.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pinta23.09.01.020; 11.02.13.003--Not Available
Pneumonia22.07.01.003; 11.01.09.0030.000377%Not Available
Polyneuropathy17.09.03.012--Not Available
Polyuria20.02.03.002--Not Available
Portal vein thrombosis09.01.06.007; 24.01.03.003--
Proctitis herpes11.05.02.022; 07.19.04.007--Not Available
Progressive multifocal leukoencephalopathy17.16.02.002; 11.05.05.0010.000755%Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.0030.001447%
Rash23.03.13.0010.001447%Not Available
Rash generalised23.03.13.002--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.005--Not Available
Respiration abnormal22.02.08.011--Not Available
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