| Pharmaceutical Information |
| Drug Name |
Mangafodipir trisodium |
| Drug ID |
BADD_D01348 |
| Description |
Mangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas. This drug is made up of paramagnetic manganese (II) ions combined with the chelating agent _fodipir_ (dipyridoxyl diphosphate, DPDP). Manganese absorption into the tissues that makes the normal tissue appear brighter in MRI is limited in abnormal or cancerous tissue. Enhanced contrast by mangafodipir improves visualization and detection of lesions of the liver formed from metastatic disease or hepatocellular carcinomas. The contrast agent is present as mangafodipir trisodium marketed under the name Teslascan. Teslascan has been removed from the Drug Product List by FDA in 2003, and withdrawn from the European market in 2012. |
| Indications and Usage |
Indicated for use as an organ-specific paramagnetic contrast agent developed for imaging of the hepatobiliary system and detecting lesions in liver and pancreas. |
| Marketing Status |
Discontinued |
| ATC Code |
V08CA05 |
| DrugBank ID |
DB06796
|
| KEGG ID |
D04848
|
| MeSH ID |
C060076
|
| PubChem ID |
160036
|
| TTD Drug ID |
D04BKZ
|
| NDC Product Code |
65392-2204 |
| Synonyms |
N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid | DPDP | mangafodipir | manganese-DPDP | Mn-DPDP | manganese dipyridoxyl diphosphate | Teslascan | calmangafodipir | Ca4Mn(DPDP)5 | mangafodipir trisodium | mangafodipir trisodium, anhydrous |
|
| Chemical Information |
| Molecular Formula |
C22H27MnN4Na3O14P2 |
| CAS Registry Number |
140678-14-4 |
| SMILES |
[H+].[H+].[H+].CC1=NC=C(C(=C1[O-])CN(CCN(CC2=C(C(=NC=C2COP(=O)([O-])[O-])C)[O-])
CC(=O)[O-])CC(=O)[O-])COP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Mn+2] |
| Chemical Structure |
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| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
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| ADRs Induced by Drug |
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