Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chills08.01.09.001; 15.05.03.0160.010970%
Choking22.02.05.0010.004619%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.002021%Not Available
Cholecystitis09.03.01.0010.001155%
Cholecystitis acute09.03.01.0030.001443%Not Available
Cholelithiasis09.03.01.0020.004619%Not Available
Chromaturia20.02.01.0020.002887%
Chronic obstructive pulmonary disease22.03.01.0070.006778%Not Available
Clavicle fracture12.04.01.010; 15.08.03.0100.000577%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.002598%Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.0010.002598%
Colon cancer07.21.01.001; 16.13.01.0010.000602%Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Compression fracture15.08.02.004; 12.04.02.0080.000577%Not Available
Concussion17.11.01.004; 12.01.10.0050.000866%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coordination abnormal17.02.02.0040.000866%Not Available
Cor pulmonale24.08.03.001; 02.05.03.001; 22.06.01.0030.000602%Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.006--Not Available
Cough22.02.03.0010.068704%
Crepitations08.01.03.0060.000577%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.004041%
Cyst16.02.02.002; 08.03.05.0010.001155%Not Available
Cystitis20.03.02.002; 11.01.14.0010.006351%
Deafness04.02.01.0010.003753%Not Available
Death08.04.01.0010.126590%
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