Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loxapine succinate
Drug ID BADD_D01327
Description An antipsychotic agent used in schizophrenia. [PubChem]
Indications and Usage For the management of the manifestations of psychotic disorders such as schizophrenia
Marketing Status Prescription; Discontinued
ATC Code N05AH01
DrugBank ID DB00408
KEGG ID D00794
MeSH ID D008152
PubChem ID 71399
TTD Drug ID D0U5OE
NDC Product Code 64330-112; 53296-0017
Synonyms Loxapine | 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine | Oxilapine | Cloxazepine | Loxapine Hydrochloride | Hydrochloride, Loxapine | Loxitane | Loxapine Succinate | Succinate, Loxapine | Loxapinsuccinate | Loxipine Succinate | Loxipine Maleate | Maleate, Loxipine | CL-71,563 | CL 71,563 | CL71,563 | Loxapine Monohydrochloride
Chemical Information
Molecular Formula C22H24ClN3O5
CAS Registry Number 27833-64-3
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.C(CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Akinesia17.01.02.003--Not Available
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Asthenia08.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance08.01.02.002; 17.02.05.016--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hyperpyrexia08.05.02.002--Not Available
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
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