Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Marketing Status OTC; Discontinued
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 51672-2085; 71335-1461; 52904-630; 72288-446; 21130-452; 55910-807; 63868-462; 0363-2131; 36800-363; 51660-754; 61474-4268; 50090-1454; 70000-0473; 61919-142; 67751-153; 55910-594; 24385-543; 11523-4329; 71335-0100; 37012-612; 67091-245; 11523-4359; 11523-7333; 0363-1612; 41250-612; 16714-898; 70518-2951; 54838-558; 54838-554; 63868-577; 53943-035; 49452-4135; 62207-787; 72288-901; 0363-0858; 24385-531; 56062-132; 81646-106; 11523-7157; 49348-818; 73581-203; 69168-414; 51927-4219; 68391-314; 11014-0031; 70000-0125; 50090-4316; 53943-975; 68071-4910; 30142-612; 41250-629; 55910-539; 50268-489; 11673-997; 21130-999; 71335-1651; 65015-803; 59556-301; 11523-4328; 63940-904; 56062-526; 66267-653; 68210-4110; 11523-1527; 79481-0446; 62938-0005; 71610-423; 55700-097; 80070-110; 0363-9995; 11822-3276; 0363-4020; 55154-4375; 68196-301; 68788-7653; 51660-753; 11822-0558; 55910-970; 0113-1191; 51079-246; 69842-337; 68016-131; 46122-539; 41163-364; 55910-612; 71309-007; 68016-167; 67751-163; 69842-085; 49035-953; 70677-0029; 41520-510; 59556-882; 63941-193; 25000-021; 50090-0836; 51672-2108; 59651-074; 51672-2092; 58602-830; 0904-6767; 55319-099; 73629-003; 70518-1335; 62993-0801; 37808-131; 72036-193; 63868-414; 11822-0446; 63941-131; 30142-723; 55910-611; 36800-755; 57344-193; 63187-100; 10888-8213; 11673-115; 53002-7490; 72983-501; 51001-2213; 63827-0001; 11822-2131; 11523-7202; 11523-6655; 70518-1399; 68071-4318; 70010-162; 0363-2108; 69842-686; 80159-103; 69230-322; 58602-821; 71610-553; 68071-4121; 30142-066; 0363-0699; 53117-407; 51660-527; 0615-8217; 59556-917; 0363-9603; 51660-112; 60000-950; 41163-633; 66577-046; 0113-0671; 53943-193; 11523-4331; 70677-0134; 66577-012; 50090-4300; 11523-7160; 50090-5532; 0113-1612; 62011-0371; 21130-139; 11523-7200; 0904-6852; 69842-894; 21130-301; 69842-540; 68788-7291; 68016-094; 50090-4266; 68554-0003; 41250-890; 65015-684; 53117-309; 41520-612; 41226-686; 49035-806; 68788-7769; 71141-132; 70677-0145; 63941-526; 70518-0135; 69842-954; 56062-990; 51660-106; 69842-895; 0363-1686; 0363-0754; 11673-996; 62011-0248; 55681-303; 11523-4360; 41250-716; 47682-913; 80070-120; 56062-900; 49035-061; 72288-612; 68071-2392; 63654-309; 51672-2131; 55910-629; 0904-6632; 38779-2857; 50090-2387; 0363-0752; 45802-650; 68391-301; 57243-200; 0113-7612; 65691-0042; 11523-0007; 30142-984; 21130-646; 36800-853; 68071-3208; 51316-502; 0113-9755; 37808-529; 55301-612; 17856-0557; 70000-0583; 69842-953; 59726-915; 54473-166; 11673-111; 37205-378; 62938-0004; 68210-4126; 55289-728; 0113-7671; 41163-612; 36800-608; 58602-744; 63552-038; 72983-500; 63629-7772; 68998-309; 70000-0252; 43353-259; 51672-2073; 59726-758; 63868-669; 49035-538; 59651-035; 55154-4976; 69168-407; 0113-7500; 37808-506; 16571-822; 59779-528; 63629-1329; 69848-019; 11822-7240; 69842-535; 11822-8329; 68001-438; 0113-1719; 0363-9150; 69842-242; 50090-5506; 41520-716; 11523-7237; 70000-0213; 50090-5067; 41250-539; 67091-350; 68998-407; 69452-283; 69168-309; 68071-5049; 72888-029; 68071-2208; 0113-0612; 67091-246; 11523-0800; 30142-996; 63548-0753; 62331-018; 0536-1092; 55315-528; 53943-116; 50090-3464; 51316-503; 50090-3943; 68016-053; 65015-802; 68016-088; 51824-075; 58602-831; 63981-612; 62011-0348; 69452-211; 46122-423; 21130-123; 68016-055; 72288-200; 50804-840; 81522-612; 69256-612; 51660-526; 11822-2022; 55154-8082; 11673-986; 11523-4330; 11822-0919
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tension19.06.02.0050.000146%Not Available
Throat irritation22.02.05.013; 07.05.03.0040.000291%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.000219%
Urticaria23.04.02.001; 10.01.06.0010.000291%
Viral infection11.05.04.001--Not Available
Vision blurred06.02.06.007; 17.17.01.0100.000219%
Visual impairment06.02.06.0080.000219%Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.0090.000146%
Musculoskeletal disorder15.03.01.0040.000146%Not Available
Emotional distress19.04.02.0080.000510%Not Available
Deep vein thrombosis24.01.02.0030.000291%Not Available
Nasal discomfort22.02.05.0200.000146%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Intestinal haemorrhage07.12.03.005; 24.07.02.0310.000219%Not Available
Decreased appetite08.01.09.028; 14.03.01.0050.000219%
Ill-defined disorder08.01.03.049--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Oropharyngeal discomfort22.02.05.027; 07.05.05.0080.000146%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.000146%
Use of accessory respiratory muscles22.02.08.0170.000146%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000291%Not Available
Cartilage injury15.07.03.005; 12.04.03.0070.000146%Not Available
Spinal column stenosis15.10.04.003; 17.10.01.0110.000146%Not Available
Clostridium difficile infection11.02.02.0090.000146%Not Available
Biliary dyskinesia09.03.02.0040.000146%Not Available
Sopor19.02.04.002; 17.02.04.0210.000146%Not Available
Foot deformity15.10.03.0050.000146%Not Available
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