Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide mesylate
Drug ID BADD_D01312
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09638
MeSH ID C473731
PubChem ID 11274333
TTD Drug ID D0H8VY
NDC Product Code 76431-120; 48957-0086; 76431-110; 11014-0359; 70600-005; 76431-105; 11014-0362; 11014-0360; 11014-0460; 66039-923; 11014-0459; 11014-0361; 11014-0461; 76431-130
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C40H41F6N3O5S
CAS Registry Number 202914-84-9
SMILES CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6 =CC=CC=C64)C(=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityCytochrome P450 3A4P08684T37848Not Available
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Alanine aminotransferase13.03.01.031--Not Available
Alanine aminotransferase increased13.03.01.003--
Angina pectoris24.04.04.002; 02.02.02.002--
Aspartate aminotransferase13.03.01.032--Not Available
Back pain15.03.04.005--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Constipation07.02.02.001--
Defaecation urgency07.02.04.001--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Headache17.14.01.001--
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Influenza11.05.03.001; 22.07.02.001--Not Available
Laryngeal pain22.02.05.036--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Palpitations02.01.02.003--
Pyrexia08.05.02.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
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