Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
TeratogenicityCytochrome P450 3A4P08684T3784826240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug interaction08.06.03.001--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.0010.000241%
Dyspepsia07.01.02.0010.000965%
Dysphagia07.01.06.0030.000422%
Dyspnoea22.02.01.004; 02.01.03.002--
Ear disorder04.03.01.001--Not Available
Ear infection11.01.05.001; 04.03.01.0060.000181%Not Available
Eating disorder19.09.01.008; 14.03.01.0080.000121%Not Available
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Eructation07.01.02.0030.000181%
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye infection11.01.06.001; 06.04.05.0070.000121%
Eye swelling06.08.03.003--Not Available
Faeces discoloured07.01.03.0020.000181%Not Available
Faeces hard07.01.03.003--Not Available
Fatigue08.01.01.0020.002052%
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.0020.003440%
Fluid retention14.05.06.002; 20.01.02.003--Not Available
Foot fracture15.08.03.012; 12.04.01.0120.000181%Not Available
Frequent bowel movements07.02.04.0020.000302%Not Available
Fungal infection11.03.05.0010.000181%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.011--
Gastric dilatation07.02.02.002--Not Available
Gastritis07.08.02.0010.000181%
Gastrooesophageal reflux disease07.02.02.0030.000784%
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